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Amaryl prescription: Glimepiride is used along with diet and exercise to treat type-2 diabetes. It works by helping the pancreas to make more insulin while also making the body more sensitive to insulin. You should not use this drug if you are allergic to it or to other similar drugs called sulfonylureas (e.g. tolbutaminde, glyburide, gliclazide, chlorpropramide). This drug should not be used and will not work if you have type-1 diabetes. Before taking this medication, tell your doctor specifically if you have or have ever had:
* kidney disease or lactic acidosis
* an allergic reaction to sulfa-like drugs (e.g. Septra, sulfamethoxazole) - you may have an increased risk to an allergic reaction but overall, your risk is likely minimal
* low blood sugar (hypoglycemia)
* difficulty eating 2-3 meals per day
* problems with the liver
Amaryl use: Glimepiride is in a class of drugs called sulfonylureas. It is used to help control blood sugar levels. Glimepiride is used with diet and exercise to treat noninsulin-dependent (Type II) diabetes mellitus (NIDDM). Insulin or metformin (Glucophage) may also be used in combination with glimepiride, if necessary.
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Why is this drug prescribed?
Amaryl tablets contain the active ingredient glimepiride, which is a type of drug called a sulphonylurea. Glimepiride is also available without a brand name, ie as the generic drug. Glimepiride is used to help control blood sugar levels in people with type 2 diabetes.
People with type 2 diabetes have a deficiency of a hormone called insulin. Insulin is produced by the pancreas and is the main hormone responsible for controlling sugar levels in the blood. It normally makes the cells of the body remove excess sugar from the blood. In type 2 diabetes insulin is produced inefficiently in response to surges of blood sugar, eg following a meal. The cells of the body also become resistant to the action of insulin that is produced, which means that blood sugar levels can become too high.
Glimepiride works mainly by stimulating the cells in the pancreas that produce insulin. These cells are called beta cells. Glimepiride causes the beta cells to produce more insulin and this insulin removes sugar from the blood.
Glimepiride also increases the uptake of sugar from the blood into muscle and fat cells and decreases the production of sugar by the liver.
All these actions help to decrease the amount of sugar in the blood of people with type 2 diabetes.
Glimepiride tablets are normally taken once a day, shortly before or during the first meal of the day.
Glimepiride is a first line option for treating type 2 diabetes in people who are not overweight. It is used when diet and exercise have failed to control blood sugar levels. It can also be used in combination with other antidiabetic drugs to provide better control of blood sugar.
Treatments
* Type 2 diabetes, when diet has failed to fully control blood sugar.
What side effects can this drug cause?
* Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
* Temporary visual disturbances at start of treatment
* Weight gain
* Low blood sugar level
* Allergic skin reactions such as rash or itching
* Disturbance in liver function
* Inflammation of the liver
* Cholestatic jaundice
* Disturbance in the normal numbers of blood cells in the blood
* Allergy to active ingredients |
