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Colchicine prescription: Colchicine relieves swelling and pain caused by attacks of gout or gouty arthritis. It may also be taken regularly to prevent gout or gouty arthritis attacks. Colchicine comes as a tablet to take by mouth. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take colchicine exactly as directed. If you are taking colchicine to relieve gout attack symptoms, start taking it at the first sign of pain. Relief usually begins within 12 hours, and symptoms disappear within 48-72 hours.
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Why is this drug prescribed?
Colchicine was originally extracted from the autumn crocus but is now synthesised.
Colchicine binds to a substance found in white blood cells.
In gout, crystals of uric acid are deposited in certain joints. White blood cells migrate to the areas of the body where uric acid has been deposited. They attempt to engulf the crystals, and, as a result,lactic acid and pro-inflammatory enzymes are released. These substances give rise to the characteristic pain and swelling of gout.
Colchicine inhibits the migration of the white blood cells into the inflamed area, causing a reduction in pain and inflammation.
Treatments
* Acute gout
* Short-term prevention of gout
What side effects can this drug cause?
* Rash
* Diarrhoea
* Decreased production of blood cells by the bone marrow
* Bleeding from the stomach
* Damage to the liver
* Damage to the kidneys
* Abdominal pain
* Nausea and vomiting
* Blood disorders
* Disorder of the muscles
* Loss of hair
* "Pins and needles" sensation in hands and feet |