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Starlix prescription: Nateglinide is an oral drug used to lower blood sugar (glucose) levels in type 2 diabetes. It is in a class of drugs called meglitinides which also includes repaglinide (Prandin). Approximately 90% of patients with diabetes have type 2 diabetes. Type 2 diabetes usually occurs in adults and is associated with obesity and a strong family history of diabetes. Insulin is an important hormone that controls the blood level of glucose. Type 2 diabetics have an inability to control blood glucose levels. This is caused by reduced secretion of insulin from the pancreas after meals and resistance of the body's cells to the effect of insulin which is to stimulate the cells to remove glucose from the blood. This leads to high levels of blood glucose. Nateglinide stimulates cells in the pancreas to produce insulin in a manner similar to the class of drugs called sulfonylureas, e.g., glyburide (Diabeta, Glynase and Micronase) which also are used in type 2 diabetes. However, nateglinide appears to have a faster onset and a shorter duration of action than sulfonylureas. The benefit of this faster, shorter effect may be to prevent the rapid, transient rise in blood glucose that occurs in diabetics immediately following a meal. Nateglinide is used to control blood glucose levels in type 2 diabetes. It may be used with diet and exercise when diet and exercise alone are not successful in controlling blood glucose. It also may be used with metformin, another drug that is used for controlling blood glucose in type 2 diabetes. Nateglinide is not recommended if blood glucose levels have not been controlled by a sulfonylurea since nateglinide and sulfonylureas have a similar mechanism of action.
Starlix use: Starlix is indicated for the treatment of patients with type 2 diabetes which cannot be controlled by diet and physical exercise alone. StarlixR can be used as monotherapy or in combination with other antidiabetic agents with a complementary mode of action, such as metformin. This may be of particular value in obese patients as very limited weight gain is reported with either StarlixR or metformin. StarlixR can be administered in dosages of 60 and 120 mg, both of which have been shown to be safe and well tolerated (Novartis data on file), although 120 mg is the recommended initial dose.
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This belongs to the group of medicines known as antidiabetics.

Starlix can be used to treat Type 2 (non-insulin dependent) diabetes mellitus, alongside another antidiabetic medicine called metformin.

Insulin is made naturally in the pancreas. It regulates the amount of sugar in the blood. If the body does not make enough insulin to meet its needs, or does not properly use the insulin it makes, this results in the condition called diabetes mellitus (sugar diabetes).

Starlix works by speeding up the release of insulin from the pancreas.

Starlix is available in tablet form.

It is also sometimes known as: Starlix. You may notice the use of any of these names on the packaging of your medicine.


Why is this drug prescribed?

People with type 2 diabetes have a deficiency of a hormone called insulin. Insulin is produced by the pancreas and is the main hormone responsible for controlling sugar levels in the blood. It normally makes the cells of the body remove excess sugar from the blood. In type 2 diabetes the cells of the body are also resistant to the action of insulin, which means that blood sugar levels can become too high. Nateglinide is an antidiabetic drug that is used to help lower blood sugar in people with type 2 diabetes. It works by acting on the cells in the pancreas that produce insulin. These cells are called beta cells. Nateglinide causes the beta cells to produce more insulin. Nateglinide is taken before meals so that insulin production is enhanced immediately after eating. This is called early or first phase insulin secretion, and does not normally happen in people with with type 2 diabetes. The enhanced insulin production starts about 15 minutes after taking the dose of nateglinide, and the result is a blood sugar lowering effect throughout and following the meal, as occurs naturally in non-diabetic people. Nateglinide is used in combination with metformin, in people whose type 2 diabetes is not controlled by the maximum dose of metformin alone. Since metformin mainly helps reduce blood sugar levels between meals, and nateglinide reduces mealtime blood sugar levels, the combination of the two provides an additive effect on blood sugar control.

Treatments

* Additional treatment of type 2 diabetes that is poorly controlled by metformin alone

What side effects can this drug cause?

* Headache * Abdominal pain * Diarrhoea * Low blood glucose level * Indigestion * Alteration in results of liver function tests * Allergic skin reactions
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