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Xenical used: This medication is used with a reduced-calorie diet to help significantly overweight persons lose weight. It also helps to prevent regaining weight previously lost. Orlistat works by blocking some of the fat normally digested by the intestine. Xenical (Orlistat) blocks some of the fat that you eat from being absorbed by your body. Orlistat is used in the management of obesity including weight loss and weight maintenance when used with a reduced-calorie diet.
Xenical prescription: Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. In the intestine, an enzyme called lipase (produced primarily by the pancreas) breaks apart fat in food so that it can be absorbed into the body. Orlistat blocks the action of lipase and thereby prevents the breakup and absorption of fat. Orlistat blocks absorption of about 25% of the fat in a meal. The unabsorbed fat is excreted in the stool. Orlistat is combined with a reduced-calorie diet to promote weight loss. Orlistat also may be used to prevent weight gain after weight has been lost. Candidates for treatment with orlistat are patients who are obese with a body mass index (a measure of obesity) of more than 30 kg/m2. Candidates also include patients with a body mass index of between 27 and 30 kg/m2 if other risk factors for arteriosclerosis are present such as high blood pressure, diabetes, and elevated blood cholesterol or triglycerides. Based on several scientific studies, the average weight loss that is achieved when orlistat is taken as recommended for six months to one year is 12.4 to 13.4 pounds.
Xenical use: Orlistat (Xenical) is used to help obese people lose weight and keep the weight off while eating a reduced-calorie diet. Orlistat decreases the amount of fat that is absorbed from your diet. Generic orlistat capsules are not yet available.
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Type of medicine Anti-obesity drug
Used for Treatment of obesity along with a reduced-calorie diet
Also called Xenical
Available as Capsules

Xenical is not absorbed into the bloodstream, but works locally in the stomach and small intestine, where it prevents the action of two enzymes found in the digestive juices. These enzymes, called gastric and pancreatic lipases, normally break down fats that we consume in our diet.


Why is this drug prescribed?

Xenical capsules contain the active ingredient orlistat, which is a type of drug called a lipase inhibitor. It is used to aid weight loss in people who are obese. Orlistat is not absorbed into the bloodstream, but works locally in the stomach and small intestine, where it prevents the action of two compounds found in the digestive juices. These compounds are called gastric and pancreatic lipases. They normally break down fats that we consume in our diet. The fats we consume in our diets are made of molecules that are too large to be absorbed from the gut into the bloodstream. They need to be broken down into smaller molecules during the process of digestion, in order to be absorbed into the bloodstream. Gastric and pancreatic lipases are the compounds in the gut that carry out this function. Orlistat works by preventing gastric and pancreatic lipases from working. It is taken at mealtimes to prevent fat that is eaten in the meals from being broken down and absorbed by the body. This means the body cannot use the fat as a source of energy, or convert it into fat tissue. Instead, the fat is excreted in the faeces. This helps weight loss. Orlistat is prescribed to aid weight loss in obese people who have a body mass index of 30kg/m or more. It can also be prescribed to overweight people who have a BMI of 28kg/m? or more, if they also have additional risk factors for obesity-related diseases. Orlistat should be used in conjunction with a mildly low calorie diet. Ask your doctor, pharmacist or dietician for advice on what to eat while taking orlistat. Your doctor may ask you to stop treatment if you have been unable to lose at least five per cent of your body weight after 12 weeks of treatment.

Treatments

* Obesity

What side effects can this drug cause?

* Headache * Oily spotting from the rectum * Abdominal pain or discomfort * Flatulence with discharge * Oily or fatty stools * Urgent or increased need to open the bowels * Diarrhoea * Pain or discomfort in the rectum * Infections of the airways * Low blood sugar levels in people with diabetes * Faecal incontinence * Fatigue * Urinary tract infection * Irregular menstrual cycle * Anxiety * Tooth or gum disorders * Diverticulitis * Gall stones * Raised liver enzymes * Inflammation of the liver